On the morning of April 23, 2026, the School of Life Sciences hosted the 37th session of the Life Science Forum. Professor Wang Fangwei from Zhejiang University delivered an academic lecture entitled Molecular Mechanisms Regulating Chromosome Stability. The forum was presided over by Secretary Lu Jiaojiao of the school. Persons in charge of grassroots teaching organizations, core research staff and postgraduate students of the school attended the event.

Accurate chromosome segregation is a core biological process for maintaining genome stability. Errors in chromosome segregation directly lead to genomic instability, which further triggers serious health problems including tumorigenesis, developmental malformations and genetic diseases.In the report, focusing on the cutting-edge scientific issue of how cells regulate mitosis to ensure accurate chromosome segregation, Professor Wang systematically reviewed the research progress in this field in a plain and thorough manner. He elaborated on key research contents, including the regulatory mechanism of the precise connection between spindle microtubules and chromosome kinetochores, the signaling pathways for G2/M checkpoint transition in cells, the dynamic regulatory network for the cohesion and sequential separation of sister chromatids, and the maintenance of centromere signaling homeostasis. He sorted out the complete regulatory logic of chromosome stability step by step, and analyzed the internal correlation between chromosomal instability and malignant tumor progression. He also presented the full-chain research ideas ranging from basic molecular mechanisms to translational applications for anti-cancer targeting.

The report featured cutting-edge content, rigorous logic and easy-to-understand explanations, combining profound academic insights with great inspiration, and benefited all teachers and students present. After the lecture, Professor Wang engaged in in-depth academic exchanges with the audience. He gave detailed answers to questions concerning molecular mechanisms, experimental design, research transformation and interdisciplinary research, creating a strong academic atmosphere.