基本介绍

      浙江中医药大学生命科学学院院长兼党委副书记、浙江中医药大学分子医学研究所所长，国家中医药管理局重点实验室（三级脂代谢实验室）负责人，美国芝加哥伊利诺伊大学访问学者。入选首批浙江省高校领军人才培养计划，荣获浙江省“杰青”、浙江省优秀教师等荣誉。    

兼任中国中西医结合学会实验医学专业委员会副主任委员、中国中西医结合学会科研院所委员会秘书长、浙江省中西医结合学会实验医学专业委员会主任委员、浙江省生物信息学会微生物组学专业委员会副主委、中国生化与分子生物学学会脂质与脂蛋白专业委员会委员等学术兼职。

主要研究方向为代谢性疾病的分子机制及中医药防治研究。获国家自然科学基金（4项）等科研项目20余项，在国内外学术期刊发表学术论文130余篇，其中在Science、Journal of Hepatology、Hepatology、AJP、BJP、Phytomedicine等国际权威期刊发表论文70余篇，获得省部级等科研奖励6项，授权国家发明专利8项，主编行业规划教材等书籍3部。

教育背景

1995 年—2000 年，张家口医学院， 临床医学，学士

2001 年—2004 年，浙江中医药大学，生命科学学院，硕士研究生

2004 年—2007 年，北京中医药大学，基础医学院，博士研究生

工作经历

2021 年-至今，浙江中医药大学，生命科学学院，教授，院长/党委副书记（兼研究所所长）

2017 年-2020 年，浙江中医药大学，生命科学学院，教授，党总支书记/副院长（兼研究所所长）

2014 年-2017 年，浙江中医药大学，生命科学学院，教授/副院长（兼研究所所长）

2010 年-2012 年，美国芝加哥伊利诺伊大学，应用健康科学学院，博士后（访问学者）

2009 年-2014 年，浙江中医药大学，生命科学学院，副教授/研究所副所长

2005 年-2009 年，浙江中医药大学，生命科学学院，细胞生物学，助教

荣誉及奖励

（1）批浙江省高校领军人才培养计划（“5246”人才工程）

（2）浙江省省级优秀教师

（3）浙江省自然科学基金项目（杰出青年）获资助者

（4）浙江省高校中青年学术带头人

（5）浙江省“151”人才工程获资助者

（6）浙江中医药大学首批“5151”人才获资助者（远志学者）

（7）窦晓兵、李松涛、王萃、纪云西、刘庆生、杜仲燕、蒋福升、丁滨、柴惠、卢德赵、田璐璐、杨贞，“益气化浊祛瘀法”治疗代谢相关脂肪性肝病的机制创新及临床应用，中国中西医结合学会科学技术奖二等奖，2023

（8）窦晓兵、 李松涛、 王兴亚、杜仲燕、宋忠诚，酒精性脂肪肝的发病新机制及中药干预研究，浙江省自然科学奖三等奖，2020

（9）陈永平、窦晓兵、李松涛、单毓娟、郑明华、陈达之、张亚利、许烂漫，脂肪性肝病“肠肝轴”关键分子机制创新与临床转化，中华医学会医学科学技术奖三等奖，2021

（10）窦晓兵、胡林峰、 柴惠、丁滨、杜仲燕、马旺、张福利、丁蕾、钱倩宇，4-HNE 抑制 TNF-α 介导的 NF-κB 信号通路诱导酒精性肝病的发生机制研究，浙江省医药卫生科技奖三等奖，2016

（11）刘庆生、窦晓兵、周卫民、桑怡、叶蔚，基于 JNK 信号通路研究半胱氨酸/不饱和脂肪酸协同诱导非酒精性脂肪肝的发病机制，浙江省医药卫生科技奖三等奖，2018

（12）沃兴德、范春雷、窦晓兵、钱颖、洪行球、唐利华、卢德赵、沃立科、严瑾、罗艳，爪蟾卵母细胞的基因表达和降脂中药的高效选择，浙江省中医药科学技术创新奖 1 等奖，2006

（13）范春雷、沃兴德、窦晓兵、洪行球、卢德赵、钱颖、唐利华，中药降脂与细胞固醇调控系统的研究，浙江省高校科研成果奖 2 等奖，2010

（14）沃兴德、范春雷、窦晓兵、钱颖、洪行球、唐利华、卢德赵，爪蟾卵母细胞的基因表达和降脂中药的高效选择，浙江省科学技术奖三等奖，2009

研究领域

代谢性疾病的分子机制及中医药防治研究

近年研究项目

1. 国家自然科学基金项目（82374102），42 万，泻浊调脂方通过“肝-肠”对话调节肌苷-LACC/A2AR-嘌呤代谢通路抗非酒精性脂肪性肝炎的作用及机制研究。

2. 国家自然科学基金项目（81773981），55 万，丹参酚酸 A 通过激活Sirt3 调控线粒体自噬防治酒精性肝病的作用机制研究。

3. 国家自然科学基金项目（81473393），75 万，丹参酮 IIA 清除 4-羟基壬烯醛治疗酒精性肝病的调控机制研究。

4. 国家自然科学基金项目（81241145），10 万，4-HNE 抑制 TNF-α 介导的 NF-κB 信号通路诱导酒精性肝病的发生机制研究。

5. 浙江省自然科学基金项目（LR15H030003），30 万，4-羟基壬烯醛诱导的脂肪功能紊乱在酒精性肝病发病中的作用机制研究。

6. 浙江省自然科学基金（LY12C07002），8 万；4-HNE 促 TNF 介导的酒精性肝损伤的调控研究，2012 年 1 月至 2013 年 12 月，主持结题。

7. 国家重点基础研究发展计划(973 计划) 2014CB543000，1500 万；“上火”的机理与防治研究（排名 5/15）。

代表性成果

[1] Le, Y., Guo, J., Liu, Z., Liu, J., Liu, Y., Chen, H., Qiu, J., Wang, C., Dou, X., Lu, D. Calenduloside E ameliorates non-alcoholic fatty liver disease via modulating a pyroptosis-dependent pathway. Journal of Ethnopharmacology, 2024, 319, 117239 . DOI: 10.1016/j.jep.2023.117239.

[2] Qiu, J., Chen, L., Zhang, L., Xu, F., Zhang, C., Ren, G., Chang, K., He, G., Du, Z., Le, Y., Yu, Z., Li, S., Liu, Q., Dou, X. Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy. Phytomedicine, 2023, 121, 155111. DOI: 10.1016/j.phymed.2023.155111.

[3] Hua, C., Jiang, F., Wang, L., Peng, S., Gao, H., Mo, W., Yan, S., Dou, X., Li, S., Zhang, C., Li, M.Protective effects of Pimpinella diversifolia DC. root essential oil against lipopolysaccharide/D-galactosamine-induced acute liver injury in mice through inhibiting inflammation and reducing oxidative stress. Arabian Journal of Chemistry, 2023, 16 (9), 105017 . DOI:10.1016/j.arabjc.2023.105017.

[4] Wang, Y., Wang, M., Chen, J., Li, Y., Kuang, Z., Dende, C., Raj, P., Quinn, G., Hu, Z., Srinivasan, T., Hassell, B., Ruhn, K.A., Behrendt, C.L., Liang, T., Dou, X., Song, Z., Hooper, L.V. The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9. Science, 2023, 381 (6660), pp. 851-857. DOI: 10.1126/SCIENCE.ADE0522.

[5] Chen, W., Deng, Y.-Y., Yu, J.-W., Leung, Y.-T., Bai, J.-X., Chen, Y.-J., Wu, Y., Wang, L., Fan, X.-Y., Wang, X.-Q., Hu, J., Chen, W.-H., Dou, X., Leung, K.S.-Y., Fu, X.-Q., Yu, Z.-L. A tri-herb formulation protects against ethanol-induced mouse liver injury and downregulates mitogen-activated protein kinase phosphatase 1. Phytomedicine, 2023, 114, 154802. DOI: 10.1016/j.phymed.2023.154802.

[6] Lai, S., Ma, Y., Hao, L., Ding, Q., Chang, K., Zhuge, H., Qiu, J., Xu, T., Dou, X., Li, S. 1-Methylnicotinamide promotes hepatic steatosis in mice: A potential mechanism in chronic alcohol-induced fatty liver disease. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2023, 1868 (4), 159286. DOI: 10.1016/j.bbalip.2023.159286.

[7] Pi, A., Ding, Q., Hao, L., Song, Q., Chen, L., Dou, X., Na, L., Li, S. Long non-coding RNA-EN_181 potentially contributes to the protective effects of N-acetylcysteine against non-alcoholic fatty liver disease in mice. British Journal of Nutrition, 2023, 129 (6), pp. 921-935. DOI: 10.1017/S0007114522001829.

[8] Song, Q., Chen, Y., Ding, Q., Griffiths, A., Liu, L., Park, J., Liew, C.W., Nieto, N., Li, S., Dou, X., Jiang, Y., Song, Z. MTORC1 inhibition uncouples lipolysis and thermogenesis in white adipose tissue to contribute to alcoholic liver disease. Hepatology Communications, 2023, 7 (3), p. E0059. DOI: 10.1097/HC9.0000000000000059.

[9] Ruirui Yang, Zhao, Z., Li, Y., Jiang, Y., Chai, H., Dou, X., Zhang, L. Store-Operated Calcium Channel and Inositol Triphosphate Receptor Calcium Channel Hyperactivation Inhibits Hepatocyte Autophagy to Promote Nonalcoholic Fatty Liver Disease. Biology Bulletin, 2023. DOI: 10.1134/S1062359023600514.

[10] Dou, X., Wang, X., Yu, X., Yao, J., Shen, H., Xu, Y., Zheng, B., Zhang, Z., Tan, Q., Hu, T.Increased soluble endoglin levels in newly-diagnosed type 2 diabetic patients are associated with endothelial dysfunction. Endocrine Journal, 202370 (7), pp. 711-721. DOI: 10.1507/endocrj.EJ22-0550.

[11] Liu, Y.-X., Chen, Y.-J., Xu, B.-W., Fu, X.-Q., Ding, W.-J., Li, S.-M.A., Wang, X.-Q., Wu, J.-Y., Wu, Y., Dou, X., Liu, B., Yu, Z.-L. Inhibition of STAT3 signaling contributes to the anti-melanoma effects of chrysoeriol. Phytomedicine. 2023), 109, 154572. DOI: 10.1016/j.phymed.2022.154572.

[12] Zhu, J., Chen, H., Le, Y., Guo, J., Liu, Z., Dou, X., Lu, D. Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis. Frontiers in Pharmacology, 2022, 13, 1009229. DOI: 10.3389/fphar.2022.1009229.

[13] Amin, A., Hossen, M.J., Fu, X.-Q., Chou, J.-Y., Wu, J.-Y., Wang, X.-Q., Chen, Y.-J., Wu, Y., Yin, C.-L., Dou, X.-B., Liang, C., Chou, G.-X., Yu, Z.-L. Inhibition of the Akt/NF-κB pathway is involved in the anti-gastritis effects of an ethanolic extract of the rhizome of Atractylodes macrocephala. Journal of Ethnopharmacology, 2022, 293, 115251. DOI: 10.1016/j.jep.2022.11525.

[14] Fu, A., Li, J., Ding, Q., Guo, R., Pi, A., Yang, W., Chen, Y., Dou, X., Song, Z., Li, S. Upregulation of 4-Hydroxynonenal Contributes to the Negative Effect of n-6 Polyunsaturated Fatty Acid on Alcohol-Induced Liver Injury and Hepatic Steatosis. Journal of Agricultural and Food Chemistry, 2022, 70 (21), pp. 6418-6428. DOI: 10.1021/acs.jafc.2c00852.

[15] Wang, C., Li, S., Liu, Q., Qian, Q., Fu, A., Chen, L., Zhang, L., Suzaki, T., Yu, Z., Dou, X. Ectopic accumulation of ceramide in cardiomyocytes modulates alcoholic cardiomyopathy via the TLR4-dependent pathway. Alcoholism: Clinical and Experimental Research, 2022, 46 (6), pp. 1011-1022. DOI: 10.1111/acer.14822.

[16] Zhang, B., Zhao, J., Jiang, M., Peng, D., Dou, X., Song, Y., Shi, J. The Potential Role of Gut Microbial-Derived Exosomes in Metabolic-Associated Fatty Liver Disease: Implications for Treatment. Frontiers in Immunology, 2022, 13, 893617. DOI: 10.3389/fimmu.2022.893617.

[17] Chen, H., Zhu, J., Le, Y., Pan, J., Liu, Y., Liu, Z., Wang, C., Dou, X., Lu, D. Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway. Phytomedicine, 2022, 99, 153964. DOI: 10.1016/j.phymed.2022.153964.

[18] Bao, J., Chen, J., Zhang, X., Xu, L., Fan, Y., Dou, X. Combined signatures of serum proteome and transcriptome in patients with recurrent aphthous ulcer. Oral Diseases, 2022, 28 (3), pp. 691-702. DOI: 10.1111/odi.13800.

[19] Ding, Q., Guo, R., Pei, L., Lai, S., Li, J., Yin, Y., Xu, T., Yang, W., Song, Q., Han, Q., Dou, X., Li, S. N-Acetylcysteine alleviates high fat diet-induced hepatic steatosis and liver injury via regulating the intestinal microecology in mice. Food and Function, 2022, 13 (6), pp. 3368-3380. DOI: 10.1039/d1fo03952k.

[20] Du, Z., Ma, Z., Lai, S., Ding, Q., Hu, Z., Yang, W., Qian, Q., Zhu, L., Dou, X., Li, S. Atractylenolide I Ameliorates Acetaminophen-Induced Acute Liver Injury via the TLR4/MAPKs/NF-κB Signaling Pathways. Frontiers in Pharmacology, 2022, 13, 797499 . DOI: 10.3389/fphar.2022.797499.

[21] Ma, Y., Ding, Q., Qian, Q., Feng, L., Zhu, Q., Si, C., Dou, X., Li, S. AMPK-Regulated Autophagy Contributes to Ursolic Acid Supplementation-Alleviated Hepatic Steatosis and Liver Injury in Chronic Alcohol-Fed Mice. ACS Omega, 2022. DOI: 10.1021/acsomega.2c06252.

[22] Yang, W., Zhu, L., Lai, S., Ding, Q., Xu, T., Guo, R., Dou, X., Chai, H., Yu, Z., Li, S. Cimifugin Ameliorates Lipotoxicity-Induced Hepatocyte Damage and Steatosis through TLR4/p38 MAPK- and SIRT1-Involved Pathways. Oxidative Medicine and Cellular Longevity, 2022, 2022, 4557532. DOI: 10.1155/2022/4557532.

[23] Xu, T., Song, Q., Zhou, L., Yang, W., Wu, X., Qian, Q., Chai, H., Han, Q., Pan, H., Dou, X., Li, S. Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes. Nutrition and Metabolism, 2021, 18 (1), 13 . DOI: 10.1186/s12986-021-00540-9.

[24] Zhang, L., Zhang, Y., Jiang, Y., Dou, X., Li, S., Chai, H., Qian, Q., Wang, M. Upregulated SOCC and IP3R calcium channels and subsequent elevated cytoplasmic calcium signaling promote nonalcoholic fatty liver disease by inhibiting autophagy. Molecular and Cellular Biochemistry, 2021, 476 (8), pp. 3163-3175. DOI: 10.1007/s11010-021-04150-0.

[25] Dou, X., Yang, W., Ding, Q., Han, Q., Qian, Q., Du, Z., Fan, Y., Wang, C., Li, S. Comprehensive Analysis of the Expression Profiles of Hepatic lncRNAs in the Mouse Model of Alcoholic Liver Disease. Frontiers in Pharmacology, 2021, 12, 709287. DOI: 10.3389/fphar.2021.709287.

[26] Pei, L., Le, Y., Chen, H., Feng, J., Liu, Z., Zhu, J., Wang, C., Chen, L., Dou, X., Lu, D. Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis. Fitoterapia, 2021, 152, 104922 . DOI: 10.1016/j.fitote.2021.104922.

[27] Lu, D., Le, Y., Ding, J., Dou, X., Mao, W., Zhu, J. CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway. Cell Biochemistry and Biophysics, 2021, 79 (2), pp. 239-252. DOI: 10.1007/s12013-020-00959-6.

[28] Lai, J., Qian, Q., Ding, Q., Zhou, L., Fu, A., Du, Z., Wang, C., Song, Z., Li, S., Dou, X. Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet Fed Male Mice. Frontiers in Pharmacology, 2021, 12, 614406 . DOI: 10.3389/fphar.2021.614406.

[29] Ding, Q., Ma, Y., Lai, S., Dou, X., Li, S. NNMT aggravates hepatic steatosis, but alleviates liver injury in alcoholic liver disease. Journal of Hepatology, 2021, 74 (5), pp. 1248-1250. DOI: 10.1016/j.jhep.2020.11.025.

[30] Yang, Z., Chen, Y., Yan, Z., Xu, T.T., Wu, X., Pi, A., Liu, Q., Chai, H., Li, S., Dou, X. Inhibition of TLR4/MAPKs Pathway Contributes to the Protection of Salvianolic Acid A Against Lipotoxicity-Induced Myocardial Damage in Cardiomyocytes and Obese Mice. Frontiers in Pharmacology, 2021, 12, 627123. DOI: 10.3389/fphar.2021.627123.

[31] Xiaobing Dou#, Qinchao Ding#, Shanglei Lai, Fusheng Jiang, Qing Song, Xindi Zhao, Ai Fu, Naima Moustaid-Moussa, Dongju Su*, Songtao Li*. Salidroside alleviates lipotoxicity-induced cell death through inhibition of TLR4/MAPKs pathway, and independently of AMPK and autophagy in AML-12 mouse hepatocytes. Journal of Functional Foods; 2020, (65):103691. doi.org/10.1016/j.jff. 2020.103691.

[32]  Li Zhou, Hua Ning, Haibin Wei, Tiantian Xu, Xindi Zhao, Ai Fu, Qianyu Qian, Zhen Yang, Xiaobing Dou*, Songtao Li*. A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium. Oxid Med Cell Longev. 2020,14;2020:6584059. DOI: 10.1155/2020/6584059.

[33] Songtao Li, Qianyu Qian, Na Ying, Jianfei Lai, Luyan Feng, Sitong Zheng, Fusheng Jiang, Qing Song, Hui Chai*, Xiaobing Dou*. Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice. Front Pharmacol. 2020 Nov 30;11:560905. DOI: 10.3389/fphar.2020.560905.

[34] Shushu Song, Jiafu Ying, Youni Zhang, Hongying Pan, Xianglei He, Zhiming Hu, Huiju Wang, Xiaobing Dou*, Xiaozhou Mou*. High expression of FOXO3 is associated with poor prognosis in patients with hepatocellular carcinoma. Oncol Lett. 2020 Apr;19(4):3181-3188. DOI: 10.3892/ol.2020.11430. Epub 2020 Mar 3.

[35] Xiaobing Dou#, Luyan Feng#, Na Ying, Qinchao Ding, Qing Song, Fusheng Jiang, Cui Wang*, Songtao Li*. RNA Sequencing Reveals a Comprehensive Circular RNA Expression Profile in a Mouse Model of Alcoholic Liver Disease. Alcohol Clin Exp Res. 2020 Feb;44(2):415-422. DOI: 10.1111/acer.14265. Epub 2020 Jan 9.

[36] Liuhua Pei, Yifei Le, Hang Chen, Jiafan Feng, Zhijun Liu, Ji Zhu, Cui Wang, Lin Chen, Xiaobing Dou*, Dezhao Lu*. Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis. Fitoterapia. 2021 Jul;152:104922. DOI: 10.1016/j.fitote.2021.104922. Epub 2021 May 11.

[37] Tiantian Xu # Qing Song #, Li Zhou, Wenwen Yang, Xiangyao Wu, Qianyu Qian, Hui Chai, Qiang Han, Hongzhi Pan, Xiaobing Dou*,Songtao Li*. Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes. Nutr Metab (Lond). 2021 Jan 19;18(1):13. DOI: 10.1186/s12986-021-00540-9.

[38] Jie Bao, Juan Chen, XiZhao Zhang, Li Xu, YongSheng Fan, XiaoBing Dou*. Combined signatures of serum proteome and transcriptome in patients with recurrent aphthous ulcer. Oral Dis. 2021 Feb 11. DOI: 10.1111/odi.13800. Epub ahead of print.

[39] Xiaobing Dou#, Wenwen Yang#, Qinchao Ding, Qiang Han, Qianyu Qian, Zhongyan Du, Yibin Fan, Cui Wang*, Songtao Li*. Comprehensive Analysis of the Expression Profiles of Hepatic lncRNAs in the Mouse Model of Alcoholic Liver Disease. Front Pharmacol. 2021 Jul29;12:709287. DOI: 10.3389/fphar.2021.709287.

[40]  Jianfei Lai#, Qianyu Qian#, Qinchao Ding, Li Zhou, Ai Fu, Zhongyan Du, Cui Wang, Zhenyuan Song, Songtao Li*, Xiaobing Dou*. Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High Fat Diet Fed Male Mice. Front Pharmacol. 2021 May 28;12:614406. DOI: 10.3389/fphar.2021.614406.

[41]  Bin Din#, Qinchao Ding#, Shun Zhang, Zhuo Jin, Zhaolei Wang, Songtao Li, Xiaobing Dou*. Characterization of the anti-Staphylococcus aureus fraction from Penthorum chinense Pursh stems. BMC Complement Altern Med. 2019 Aug 17;19(1):219. DOI: 10.1186/s12906-019-2632-3.

[42] Xiaobing Dou#, Songtao Li#, Linfeng Hu, Lei Ding, Yue Ma, Wang Ma, Hui Chai, Zhenyuan Song*. Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-Sglutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease. Exp Mol Med, 2018, 50(4):7. Doi.org/ 10.1038/s12276-017-0013-x.

[43]  Lei Ding, Like Wo, Zhongyan Du, Lihua Tang, Zhenyuan Song, Xiaobing Dou*. Danshen protects against early-stage alcoholic liver disease in mice via inducing PPARα activation and subsequent 4-HNE degradation. PLoS One, 2017, 12(10):e0186357. DOI: 10.1371/journal.pone.0186357.

[44] Qingsheng Liu, Ran Pan, Lei Ding, Fuli Zhang, Linfeng Hu, Bin Ding, Linwensi Zhu, Yongliang Xia, Xiaobing Dou*. Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries. Int Immunopharmacol, 2017, 49:132-141. DOI: 10.1016/j.intimp.2017.05.026.

[45]  Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song*. Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. Hepatology, 2017, 66(3):936-952. DOI: 10.1002/hep.29229.

[46] Xuanqi Ren, Cui Wang, Binbin Xie, Linfeng Hu, Hui Chai, Lei Ding, Lihua Tang, Yongliang Xia, Xiaobing Dou*. Tanshinone IIA induced cell death via miR30b-p53-PTPN11/SHP2 signaling pathway in humanhepatocellular carcinoma cells. Eur J Pharmacol, 2017,796:233-241. DOI:10.1016/j.ejphar.2016.11.046.

[47] Jiaxin Li#, Xiaobing Dou#, Songtao Li, Ximei Zhang, Yong Zeng, Zhenyuan Song*. Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation. Biochim Biophys Acta, 2015,1853: 2929-2936. DOI: 10.1016/j.bbamcr.2015.09.003.

[48]  Xiaobing Dou, Yongliang Xia, Jing Chen, Ying Qian, Songtao Li, Ximei Zhang, Zhenyuan Song*. Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease. Br J Pharmacol, 2014, 117(17):4073-4086. DOI: 10.1111/bph.12765.

[49] Zhigang Wang#, Xiaobing Dou#, Songtao Li, Ximei Zhang, Xinguo Sun, Zhanxiang Zhou, Zhenyuan Song*. Nrf2 activation-induced hepatic VLDLR overexpression in response to oxidative stress contributes to alcoholic liver disease in mice. Hepatology, 2014，59（4）：1381-1392.DOI: 10.1002/hep.26912.

[50] Zhongyan Du, Xiaobing Dou, Chenyun Huang, Jia Gao, Linfeng Hu, Jiazhen Zhu, Ying Qian, Minhua Dou, Chunlei Fan*. Preparation, Drug Releasing Property and Pharmacodynamics of Soy Isoflavone-Loaded Chitosan Microspheres. PLOS ONE, 2013,8(11):e79698. DOI: 10.1371/journal.pone.0079698.

[51] Xiaobing Dou, Chen Shen, Zhigang Wang, Songtao Li, Ximei Zhang, Zhenyuan Song*. Protection of nicotinic acid against oxidative stressinduced cell death in hepatocytes. Journal of Nutritional Biochemistry. Journal of Nutritional Biochemistry, 2013, 24:1520 – 1528. DOI:10.1016/j.jnutbio.2012.12.012.

[52] Dongfang Gu, Zhigang Wang, Xiaobing Dou, Ximei Zhang, Songtao Li, Lyndsey Vu, Tong Yao, Zhenyuan Song*. Inhibition of ERK1/2 pathway suppresses adiponectin secretion via accelerating protein degradation by Ubiquitin-proteasome system: Relevance to obesityrelated adiponectin decline.Metabolism. 2013, 62(8):1137-1148. DOI: 10.1016/j.metabol.2013.01.025.

[53] Xiaobing Dou, Songtao Li, Zhigang Wang, Dongfang Gu, Chen Shen, Tong Yao, Zhenyuan Song*.Inhibition of NF-κB Activation by 4-Hydroxynonenal Contributes to Liver Injury in a Mouse Model of Alcoholic Liver Disease. Am J Pathol, 2012, 181(5):1702-10. DOI: 10.1016/j.ajpath.2012.08.004.

[54] Zhigang Wang, Xiaobing Dou, Dongfang Gu, Chen Shen, Tong Yao, Van Nguyen, Carol Braunschweig, Zhenyuan Song*. 4-Hydroxynonenal Differentially Regulates Adiponectin Gene Expression and Secretion via Activating PPARγ and Accelerating Ubiquitin-Proteasome DegradationMolecular and Cellular Endocrinology; 2012, 349(2):222-231. DOI: 10.1016/j.mce.2011.10.027.

[55] Zhigang Wang, Xiaobing Dou, Tong Yao, Zhenyuan Song*. Homocysteine Inhibits Adipogenesis in 3T3-L1 Preadipocyte. Experimental Biology and Medicine. 2011, 236(12):1379-1388. DOI: 10.1258/ebm.2011.011234.

[56] Xiaobing Dou, Zhigang Wang, Tong Yao, Zhenyuan Song*. Cysteine aggravates palmitate-induced cell death in hepatocytes. Life Science; 2011,89(23-24):878-885. DOI: 10.1016/j.lfs.2011.09.022.

[57] Xiaobing Dou, Chunlei Fan, Like Wo, Jin Yan, Ying Qian, Xingde Wo*. Curcumin up-regulates LDL receptor expression via sterol regulatory element pathway in HepG2 cells. Planta Medica; 2008, 74(11):1374-1379. DOI: 10.1055/s-2008-1081316.

[58] Xiaobing Dou, Xingde Wo, Chunlei Fan*. Progress of Research in Treatment of Hyperlipidemia by Monomer or Compound Recipe of Chinese Herbal Medicine.Chin J Integr Med; 2008,14(1):71-75. DOI: 10.1007/s11655-008-0071-y.

发明专利

1. 窦晓兵，胡林峰,高佳,陈宣光. 新型实用专利名称：大豆异黄酮-壳聚糖缓释微囊的制备方法（申请号：201310033386.1）(申请公布号：CN 103099798 B)

2. 窦晓兵，杨俊. 新型实用专利名称: 一种胶体金-羰化青-低密度脂蛋白双标记探针制备方法（申请号：201010194631.3）（申请公布号：CN 102279258 A）

3. 李松涛，丁滨，丁秦超，柴惠，窦晓兵. Thonningianin A 在制备预防或治疗酒精性心肌病药物中的应用（专利号ZL201810699346.3），授权，2020

4. 窦晓兵,杜珊珊,丁秦超,丁滨,李松涛. 一种具有降低心脏肌酸激酶同工酶含量功能的复方组合物及应用（专利号ZL201810700525.4）, 授权，2020

5. 窦晓兵, 来建飞, 宋振远. 一种建立酒精性心肌病 C57BL/6 小鼠模型的方法（专利号ZL201710524561.5），授权，2020

6. 窦晓兵, 钱倩宇, 杜仲燕, 宋振远. 一种脂肪酸—血清白蛋白复合物及其制备方法（申请号201611195952.9 ），公开，实质审查。

联系方式：

手机：0571-86613598

E-mail：xbdou77@163.com

ORCID：0000-0002-2465-3079